杨帆

杨帆，男，1985年生于江西省。博士，美国化学学会(ACS)会员。现任职于上海交通大学医学院附属仁济医院海洋药物重点实验室；2012毕业于中国人民解放军海军军医大学，获药物化学博士学位，从事多种海洋生物的抗肿瘤和抗感染活性成分的提取分离、结构鉴定、结构修饰工作以及小分子药物先导化合物的全合成及结构优化。

于2011年赴美国国家天然产物中心，密西西比大学从事联合培养课题：1.西沙群岛海绵中抗疟疾和抗利什曼虫活性先导化合物的发现；2.生物转化工作，利用真菌结构改造海绵次生代谢产物；3.Rapamycin的结构修饰工作。

Dr. Fan Yang is a Research Scientist of Marine Natural Product 化学 with Research 内角 for Marine Drugs at Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University. Dr. Yang’s research is actively involved in the isolation, structural characterization and synthesis of bioactive secondary metabolites from marine 多孔动物门

1.海绵活性次生代谢产物的发现以及结构鉴定

2.抗肿瘤、抗感染活性海洋天然产物的结构修饰以及全合成

1. Fan Yang, Mark T. Hamann, Yike Zou,Ming-Yu Zhang, Xiao-Bin Gong, Jian-Ru Xiao, Wan-Sheng Chen, Hou-Wen Lin*, AntimicrobialMetabolites from Paracel Islands SpongeAgelasmauritiana, Journal of natural products, 75, 774-778, 2012.

2. Fan Yang, Hong-Jun Zhang, Yuan-YuanZhang, Wan-Sheng Chen, Hai-Long Yuan, Hou-Wen Lin*, A 肝炎 B VirusInhibitoryNeolignan fromHerpetospermumcaudigerum, Chemical & Pharmaceutical Bulletin, 58, 3, 402-404, 2010.

3. Fan Yang, Hong-Jun Zhang, Xiang-FangLiu, Wan-Sheng Chen, Hai-Feng Tang, Hou-Wen Lin*. Oxygenated Steroids fromMarine BryozoanBiflustragrandicella,Biochemical Systematics and Ecology, 37, 686689, 2009.

4. Fan Yang, Hong-Jun Zhang, Jiao-Tao Chen,Shu-Juan Piao, Wan-Sheng Chen, Hou-Wen Lin*. New Cytotoxic Oxygenated Sterolsfrom Marine BryozoanBugulaneritina.Natural Product Research, 25, 16, 1505-11, 2011.

5.Wei-Hua Jiao, Xiao-Jun Huang, Ji-Si Yang, FanYang，Shu-Juan Piao, HaoGao, Jia Li, Wen-CaiYe,Xin-Sheng Yao, Wan-Sheng Chen, Hou-Wen Lin*.Dysidavarones阿尔兹海默症, New Sesquiterpene Quinones from the Marine SpongeDysideaavara. Organic letters, 14,1, 202–205, 2012.

6.Xiang-Fan Liu, Yun-Long Song, Hong-Jun Zhang, Fan Yang, Hao-Bing Yu, Wei-Hua Jiao, Shu-Juan Piao, Wan-Sheng Chen,Hou-Wen Lin*.Simplextones A and B,UnusualPolyketides from the Marine SpongePlakortis simplex. Organic letters, 13, 12, 3154-7, 2011.

7.Shu-Juan Piao, Hong-Jun Zhang, Hai-Yan Lu, FanYang, Wei-Hua Jiao, Yang-Hua Yi, Wan-Sheng Chen, Hou-Wen Lin*. Hippolides A-H, Acyclic ManoalideDerivatives from the Marine SpongeHippospongialachne. Journal of natural products, 74, 5, 1248-54, 2011.

8.Hong-Jun Zhang, Yang-Hua Yi, Gen-Jin Yang, Ming-Ye Hu, Gui-越南盾 Cao, Fan Yang, Hou-Wen Lin*. Proline-ContainingCyclopeptides from the Marine SpongePhakelliafusca. Journal of natural products, 73, 4, 650–655, 2010.

9.Hong-Jun Zhang, Yang-Hua Yi, Fan Yang, Wan-Sheng Chen, Hou-Wen Lin*.Sesterterpenesand a New Sterol from the Marine SpongePhyllospongiafoliascens.Molecules,15, 2, 834-841, 2010.

10.Xiang-Fang Liu, Yang Shen, Fan Yang, Mark T. Hamann, Wei-Hua Jiao, Hong-Jun Zhang, Wan-Sheng Chen, Hou-Wen Lin*. SimplexolidesA−E and Plakorfuran A, Six Butyrate Derived Polyketides from the Marine SpongePlakortis simplex. Tetrahedron, 68,4635-4640, 2012.

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